| / English Dictionary |
LIGATION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
(surgery) tying a duct or blood vessel with a ligature (as to prevent bleeding during surgery)
Classified under:
Nouns denoting acts or actions
Hypernyms ("ligation" is a kind of...):
ligature; tying (the act of tying or binding things together)
Domain category:
surgery (the branch of medical science that treats disease or injury by operative procedures)
Hyponyms (each of the following is a kind of "ligation"):
tubal ligation (a sterilization procedure with women; both Fallopian tubes are tied in two places and the tubes removed in between the ligations)
Derivation:
ligate (bind with a bandage or ligature)
Context examples:
Such a cloning vector will usually have convenient restriction enzyme sites to facilitate the introduction of foreign DNA by ligation.
(Plasmid Cloning Vector, NCI Thesaurus)
This process involves sequence recognition, cleavage, excision and ligation by recombinases to create a contiguous protein-coding gene.
(Immunoglobulin Gene Rearrangement, NCI Thesaurus)
Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage.
(Doxorubicin, NCI Thesaurus)
Any physiologic process which occurs in response to ligation of an immunologic factor receptor with its cognate ligand, and results in a reduced number of active signaling molecules within the target cell.
(Negative Regulation of Immunologic Factor Signaling, NCI Thesaurus)
Any physiologic process which occurs in response to ligation of an interleukin receptor with a cognate ligand, and results in a reduced number of active signaling molecules within the target cell.
(Negative Regulation of Interleukin Signaling, NCI Thesaurus)
Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.
(Base Excision Repair, NCI Thesaurus)
During NER in eukaryotes, protein complexes detect DNA shape irregularities, induce cuts on each side of the lesion, remove the damaged fragment, and repair the helix by synthesis and ligation.
(Nucleotide Excision Repair Inhibition, NCI Thesaurus)
Due to ligation of CD154 to CD40 on CLL cells, this agent may induce CLL cells to express the proapoptotic molecule BID and death receptors CD95 (Fas) and DR5, rendering CLL B cells first resistant and then sensitive to Fas-mediated apoptosis.
(Autologous Ad-CD154-Transduced CLL B Cells, NCI Thesaurus)
BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription.
(CTCF Pathway, NCI Thesaurus/BIOCARTA)
NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
(Non-Homologous End-Joining Pathway, NCI Thesaurus/KEGG)
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