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LINKAGE

Pronunciation (US): Play  (GB): Play

 I. (noun) 

Sense 1

Meaning:

The act of linking things togetherplay

Classified under:

Nouns denoting acts or actions

Hypernyms ("linkage" is a kind of...):

attachment; fastening (the act of fastening things together)

Derivation:

link (connect, fasten, or put together two or more pieces)

Sense 2

Meaning:

A mechanical system of rods or springs or pivots that transmits power or motionplay

Classified under:

Nouns denoting man-made objects

Hypernyms ("linkage" is a kind of...):

mechanical system (a system of elements that interact on mechanical principles)

Derivation:

link (be or become joined or united or linked)

Sense 3

Meaning:

(genetics) traits that tend to be inherited together as a consequence of an association between their genes; all of the genes of a given chromosome are linked (where one goes they all go)play

Synonyms:

gene linkage; linkage

Classified under:

Nouns denoting attributes of people and objects

Hypernyms ("linkage" is a kind of...):

hereditary pattern; inheritance ((genetics) attributes acquired via biological heredity from the parents)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

Sense 4

Meaning:

An associative relationplay

Classified under:

Nouns denoting relations between people or things or ideas

Hypernyms ("linkage" is a kind of...):

connectedness; connection; connexion (a relation between things or events (as in the case of one causing the other or sharing features with it))

Hyponyms (each of the following is a kind of "linkage"):

link; nexus (the means of connection between things linked in series)

Derivation:

link (make a logical or causal connection)

Credits

 Context examples: 

The linkage system in SGN-LIV1A is highly stable in plasma, resulting in cytotoxic specificity against LIV-1-positive cells.

(Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A, NCI Thesaurus)

A direct linkage between an artery and a vein.

(Arteriovenous Shunt, NCI Thesaurus)

Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

(Melphalan, NCI Thesaurus)

After intratumoral injection, cisplatin alkylates guanine nucleosides in DNA, and causes DNA-DNA or DNA-protein cross-linkages, thereby preventing DNA replication and resulting in tumor cell growth inhibition and apoptosis.

(Cisplatin-E Therapeutic Implant, NCI Thesaurus)

An integrated physical and genetic linkage map of the human genome produced by the Centre d'Etude du Polymorphisme Humain (CEPH) and the Genethon research laboratories.

(CEPH/Genethon Map, NCI Thesaurus)

A family of hydrolases that cleaves alpha-linkages in polysaccharides, such as starch and glycogen, and yield glucose and maltose.

(Alpha-Amylase, NCI Thesaurus)

Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis.

(Cefepime Hydrochloride, NCI Thesaurus)

Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages.

(Melphalan-Flufenamide Prodrug, NCI Thesaurus)

The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion).

(Mitotic Sister Chromatid Cohesion, NCI Thesaurus)

A glycosylation site is an amino acid residue within a peptide that accepts oligosaccharide via amide linkage, specifically through amide nitrogen of asparagine via N-acetylglucosamine, as one of the post-translational modifications.

(N-Glycosylation Site, NCI Thesaurus)




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