| / English Dictionary |
MEDIATED
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Acting or brought about through an intervening agency
Example:
the mediated settlement brought satisfaction to both sides
Classified under:
Similar:
mediate (acting through or dependent on an intervening agency)
II. (verb)
Sense 1
Past simple / past participle of the verb mediate
Context examples:
MET inhibitor EMD 1204831 selectively binds to Met tyrosine kinase, thereby disrupting MET mediated signal transduction pathways.
(MET Tyrosine Kinase Inhibitor EMD 1204831, NCI Thesaurus)
Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways.
(MET Tyrosine Kinase Inhibitor SAR125844, NCI Thesaurus)
A melanoma monoclonal antibody, subclass IgG2A, may have potential use as a diagnostic agent and, therapeutically, may induce macrophage-mediated cytotoxicity against antibody-bound melanoma cells.
(Melanoma Monoclonal Antibody hIgG2A, NCI Thesaurus)
Upon oral administration, MEK/Aurora kinase inhibitor BI 847325 selectively binds to and inhibits the activity of MEK, which both prevents the activation of MEK-dependent effector proteins and inhibits growth factor-mediated cell signaling.
(MEK/Aurora Kinase Inhibitor BI 847325, NCI Thesaurus)
MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
(MEK Inhibitor AZD8330, NCI Thesaurus)
MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
(MEK Inhibitor GDC-0623, NCI Thesaurus)
Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling.
(MEK Inhibitor MEK162, NCI Thesaurus)
Metformin may exert antineoplastic effects through AMPK-mediated or AMPK-independent inhibition of mammalian target of rapamycin (mTOR), which is up-regulated in many cancer tissues.
(Metformin hydrochloride, NCI Thesaurus)
The monomer form of this agent has relaxation effect on smooth muscle systemically, which might be a result of nitric oxide-mediated response.
(Methyl Methacrylate, NCI Thesaurus)
Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle.
(Metoclopramide, NCI Thesaurus)
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