MELPHALAN

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

Antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies

Synonyms:

Alkeran; melphalan

Classified under:

Nouns denoting man-made objects

Hypernyms ("melphalan" is a kind of...):

antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)

Credits

Context examples:

Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA.

(Melphalan Hydrochloride, NCI Thesaurus)

When co-administered with alkylating agent melphalan, which utilizes amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity.

(Glutaminase-Asparaginase, NCI Thesaurus)

HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.

(HL-60/MX2, NCI Thesaurus)

Also called melphalan.

(Alkeran, NCI Dictionary)

HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.

(HL-60/MX1, NCI Thesaurus)

A melphalan prodrug in which the alkylating agent melphalan is bound to flufenamide, with potential antineoplastic and anti-angiogenic activities.

(Melphalan-Flufenamide Prodrug, NCI Thesaurus)

Upon administration, melphalan is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA; RNA and proteins may also be alkylated.

(Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex, NCI Thesaurus)

Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages.