| / English Dictionary |
MICROTUBULE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A microscopically small tubule
Classified under:
Hypernyms ("microtubule" is a kind of...):
tubule (a small tube)
Context examples:
Microfilaments physically associate with microtubules to play a structural role in cytoskeleton integrity.
(Microfilament Protein, NCI Thesaurus)
The proteins are required for both microtubule assembly and stabilization.
(Microtubule Associated Protein, NCI Thesaurus)
Any microtubule process involving the removal of tubulin heterodimers from one or both ends of a microtubule.
(Microtubule Depolymerization Process, NCI Thesaurus)
Microtubules (MTs) are a major component of this cellular support structure.
(Microtubules’ role in heart cell contraction revealed, NIH)
Ansamitomicin P-3 binds to tubulin at the maytansine-binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis.
(Ansamitomicin P-3, NCI Thesaurus)
The drug combination preserved microtubule structure in human stem cell-derived neurons, and rat retina—the light sensitive tissue at the back of the eye.
(Researchers develop “hibernation in a dish” to study how animals adapt to the cold, National Institutes of Health)
Stabilization of microtubule polymerization causes interruption of mitosis and is the mode of action of several antineoplastic agents.
(Microtubule Polymerization Process, NCI Thesaurus)
After internalization, the DM1 moiety binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that express the EGFRvIII mutant.
(Anti-EGFRvIII Antibody Drug Conjugate AMG 595, NCI Thesaurus)
After internalization, the mertansine moiety binds to tubulin and interferes with microtubule assembly/disassembly dynamics.
(Anti-EGFR TAP Antibody-drug Conjugate IMGN289, NCI Thesaurus)
Microtubule dynamic alteration involves an interruption of the microtubule assembly and disassembly dynamics during cell cycle via exogenous agents.
(Microtubule Dynamics Alteration, NCI Thesaurus)
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