/ English Dictionary

MODULATE

Pronunciation (US):

(GB):

 I. (verb) 

Sense 1

Meaning:

Vary the frequency, amplitude, phase, or other characteristic of (electromagnetic waves)

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "modulate" is one way to...):

alter; change; vary (become different in some particular way, without permanently losing one's or its former characteristics or essence)

Sentence frames:

Somebody ----s something
Something ----s something

Derivation:

modulation ((electronics) the transmission of a signal by using it to vary a carrier wave; changing the carrier's amplitude or frequency or phase)

Sense 2

Meaning:

Adjust the pitch, tone, or volume of

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "modulate" is one way to...):

adjust; correct; set (alter or regulate so as to achieve accuracy or conform to a standard)

Sentence frames:

Somebody ----s something
Something ----s something

Derivation:

modulation (a manner of speaking in which the loudness or pitch or tone of the voice is modified)

Sense 3

Meaning:

Fix or adjust the time, amount, degree, or rate of

Example:

modulate the pitch

Synonyms:

modulate; regulate

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "modulate" is one way to...):

adjust; correct; set (alter or regulate so as to achieve accuracy or conform to a standard)

Sentence frames:

Somebody ----s something
Something ----s something

Derivation:

modulation (the act of modifying or adjusting according to due measure and proportion (as with regard to artistic effect))

Sense 4

Meaning:

Vary the pitch of one's speech

Synonyms:

inflect; modulate; tone

Classified under:

Verbs of telling, asking, ordering, singing

Hypernyms (to "modulate" is one way to...):

mouth; speak; talk; utter; verbalise; verbalize (express in speech)

Sentence frame:

Somebody ----s something

Derivation:

modulation (a manner of speaking in which the loudness or pitch or tone of the voice is modified)

modulation (rise and fall of the voice pitch)

Sense 5

Meaning:

Change the key of, in music

Example:

modulate the melody

Classified under:

Verbs of sewing, baking, painting, performing

Hypernyms (to "modulate" is one way to...):

play; spiel (replay (as a melody))

Domain category:

music (musical activity (singing or whistling etc.))

Sentence frame:

Somebody ----s something

Sentence example:

They will modulate the duet

Derivation:

modulation (a musical passage moving from one key to another)

Credits

 Context examples: 

The opioid receptors modulate pain signaling in response to endogenous peptide ligands and opiate drugs such as morphine.

(Pain Repression Pathway, NCI Thesaurus/BIOCARTA)

In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion.

(Panobinostat, NCI Thesaurus)

This activates interferon-mediated signal transduction pathways and induces the transcription and translation of genes with interferon-specific response elements (ISREs); the protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects.

(PEG-Proline-Interferon Alfa-2b, NCI Thesaurus)

Signaling by cytokines may modulate cell survival, proliferation, or apoptosis through modulation of p27 expression.

(p27 Regulation Pathway, NCI Thesaurus/BIOCARTA)

The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity.

(Oteracil Potassium, NCI Thesaurus)

MAX mRNA steady state level is not modulated with respect to cell proliferation or differentiation, unlike mRNAs encoded by most immediate early genes.

(Oncogene MAX, NCI Thesaurus)

While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation.

(ORC Subunit Gene, NCI Thesaurus)

This agent may also modulate multi-drug response (MDR) activity through inhibition of the p-glycoprotein efflux pump.

(Amlodipine, NCI Thesaurus)

CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates.

(Cell Cycle Pathway, NCI Thesaurus/KEGG)

This gene plays a role in signal transduction and modulates synaptic transmission.

(AKAP9 Gene, NCI Thesaurus)

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