MOIETY

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

One of two basic subdivisions of a tribe

Classified under:

Nouns denoting groupings of people or objects

Hypernyms ("moiety" is a kind of...):

social group (people sharing some social relation)

Holonyms ("moiety" is a member of...):

folk; tribe (a social division of (usually preliterate) people)

Sense 2

Meaning:

One of two (approximately) equal parts

Synonyms:

mediety; moiety

Classified under:

Nouns denoting quantities and units of measure

Hypernyms ("moiety" is a kind of...):

half; one-half (one of two equal parts of a divisible whole)

Credits

Context examples:

The monoclonal antibody moiety of DMUC5754A selectively binds to MUC16.

(MUC16-targeted Antibody-Drug Conjugate DMUC5754A, NCI Thesaurus)

In tumor cells, the NO donating moiety may block the cell cycle in the G1 and G2 phases and may induce apoptosis through caspase-mediated mechanisms.

(Nitric oxide-releasing acetylsalicylic acid derivative, NCI Thesaurus)

Upon administration, the antibody moiety of PF-06263507 selectively binds to cells expressing the 5T4 oncofetal antigen.

(Anti-5T4 Antibody-Drug Conjugate PF-06263507, NCI Thesaurus)

An adenine nucleotide comprised of three phosphate groups esterified to the sugar moiety, found in all living cells.

(Adenosine triphosphate, NCI Thesaurus)

Upon infusion of oxaliplatin-encapsulated transferrin-conjugated NGPE liposomes, the transferrin moiety targets and binds to the Tf receptor, which is overexpressed on a variety of human cancer cells.

(Oxaliplatin-Encapsulated Transferrin-Conjugated N-glutaryl Phosphatidylethanolamine Liposome, NCI Thesaurus)

The biological activity of this agent is derived from its interferon alpha-2b protein moiety.

(Peginterferon alfa-2b, NCI Thesaurus)

The PEG moiety inhibits proteolytic breakdown and clearance of IFN-a2b, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing.

(PEG-Proline-Interferon Alfa-2b, NCI Thesaurus)

The biological activity of this agent is derived from its interferon alpha-2a protein moiety.

(Peginterferon alfa-2a, NCI Thesaurus)

Following intravenous administration, aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety.

(Aldoxorubicin, NCI Thesaurus)

The Ang2/VEGF peptide moieties of Ang2/VEGF-binding peptides-antibody fusion protein CVX-241 bind to Ang2 and VEGF receptors, which may inhibit tumor angiogenesis and tumor cell proliferation.