| / English Dictionary |
MRNA
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The template for protein synthesis; the form of RNA that carries information from DNA in the nucleus to the ribosome sites of protein synthesis in the cell
Synonyms:
informational RNA; messenger RNA; mRNA; template RNA
Classified under:
Hypernyms ("mRNA" is a kind of...):
ribonucleic acid; RNA ((biochemistry) a long linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell)
Context examples:
This "messenger RNA" (mRNA) travels to the ribosome, the molecular machine that synthesizes proteins.
(Genes Can be Read in Different Ways, NIH, US)
The siRNAs bind to PKN3 mRNAs, which may result in the inhibition of translation and expression of the PKN3 protein and, so, growth inhibition of tumor cells that overexpress PKN3.
(Anti-PKN3 siRNA Atu027, NCI Thesaurus)
A prostate cancer vaccine containing mRNAs encoding prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), prostate stem cell antigen (PSCA) and six-transmembrane epithelial antigen of the prostate (STEAP), with potential antitumor activity.
(mRNA-Derived Prostate Cancer Vaccine CV9103, NCI Thesaurus)
"So we profiled every molecule of mRNA in the cells as they started to die and then as they recovered."
(Cells Back from Brink of Death, The Titi Tudorancea Bulletin)
The mRNAs used in this vaccine are modified to have enhanced translational potency and adjuvant activities.
(mRNA-derived Prostate Cancer Vaccine CV9104, NCI Thesaurus)
This nucleic acid is involved in the modulation of target gene transcription or mRNA translation.
(MIR376C Pre-miRNA, NCI Thesaurus)
The use of nucleic acid oligomers to bind to a specific mRNA to deter protein production.
(Antisense Technology, NCI Thesaurus)
Treatment using nucleic acid oligomers to bind to specific mRNA to deter protein production and alter disease process.
(Antisense therapy, NCI Thesaurus)
By nonsense-mediated decay, mRNA surveillance facilitates the detection and destruction of mRNAs that contain premature termination codons.
(mRNA Surveillance, NCI Thesaurus)
A single stranded RNA virus where the RNA strand is the complement of a mRNA.
(Negative Sense ssRNA Virus, NCI Thesaurus)
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