MUTATE

Pronunciation (US): (GB):

I. (verb)

Verb forms

Present simple: I / you / we / they mutate ... he / she / it mutates

Past simple: mutated

Past participle: mutated

-ing form: mutating

Sense 1

Meaning:

Undergo mutation

Example:

cells mutate

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "mutate" is one way to...):

change (undergo a change; become different in essence; losing one's or its original nature)

Troponyms (each of the following is one way to "mutate"):

revert (undergo reversion, as in a mutation)

Sentence frame:

Something ----s

Derivation:

mutant (an animal that has undergone mutation)

mutant ((biology) an organism that has characteristics resulting from chromosomal alteration)

mutant (tending to undergo or resulting from mutation)

mutation ((genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism)

mutation ((biology) an organism that has characteristics resulting from chromosomal alteration)

mutative (of or pertaining to or marked by genetic mutation)

Credits

Context examples:

A person who has a mutated (changed) copy of a gene.

(Mutation carrier, NCI Dictionary)

JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617.

(Momelotinib, NCI Thesaurus)

Multikinase inhibitor 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs).

(Multikinase Inhibitor 4SC-203, NCI Thesaurus)

MET tyrosine kinase inhibitor PF-02341066 blocks the protein made by the mutated ALK gene.

(MET tyrosine kinase inhibitor PF-02341066, NCI Dictionary)

Mutated Huntingtin decreases production of BDNF leading to neuronal death.

(Brain-Derived Neurotrophic Factor, NCI Thesaurus)

Blocking mutated BRAF kinase proteins may help keep cancer cells from growing.

(BRAF kinase inhibitor, NCI Dictionary)

CEP-32496 specifically and selectively inhibits the activity of the mutated form (V600E) of B-raf kinase.

(BRAF(V600E) Inhibitor CEP-32496, NCI Thesaurus)

This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs).

(Nilotinib, NCI Thesaurus)

This may inhibit IL-3-dependent signalling and proliferation and may prevent the uncontrolled growth and differentiation of mutated LSC.

(Anti-CD123 Monoclonal Antibody CSL360, NCI Thesaurus)

TGF-beta RII is mutated in a number of cancer cell types and is involved in cancer cell proliferation and tumor progression.