| / English Dictionary |
MYOSIN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The commonest protein in muscle; a globulin that combines with actin to form actomyosin
Classified under:
Hypernyms ("myosin" is a kind of...):
globulin (a family of proteins found in blood and milk and muscle and in plant seed)
Holonyms ("myosin" is a substance of...):
actomyosin (a protein complex in muscle fibers; composed of myosin and actin; shortens when stimulated and causes muscle contractions)
Context examples:
Myosin-9 (1960 aa, ~227 kDa) is encoded by the human MYH9 gene.
(Myosin-9, NCI Thesaurus)
Calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones, myosin light chain, and the regulatory subunit of cAMP-dependent protein kinase.
(Calcineurin, NLM, Medical Subject Headings)
In conjunction with myosin, actin is responsible for the contraction and relaxation of muscle.
(Actin, NCI Thesaurus)
In the nucleus NF-AT forms complexes with the GATA-4 and other transcription factors leading to activation of transcription of genes (e.g., ANF, a-actin, b-myosin, TNFa, ET-1, Adss1) essential for cardiac development.
(NFAT Pathway, NCI Thesaurus/BIOCARTA)
The subsequent activation of newly synthesized RhoA transforms these clusters into Focal Adhesion Complexes and the formation of contractile actin-myosin stress fibers.
(Calpain-1 Cell Spread Pathway, NCI Thesaurus/BIOCARTA)
These proteins play a role in the regulation of actin/myosin interactions and the subsequent mediation of smooth muscle contraction.
(Calponin, NCI Thesaurus)
Myosin-2 (1941 aa, ~223 kDa) is encoded by the human MYH2 gene.
(Myosin-2, NCI Thesaurus)
Downstream of Rac and PAK1, Myosin light chain kinase (MLCK) phosphorylates myosin light chain to increase cell migration.
(Cell Migration Pathway, NCI Thesaurus/BIOCARTA)
The system consists of many specialized cytoplasmic proteins, including actin, myosin, tubulin, kinesin, other cytoskeletal and contractile system proteins.
(Contractile System, NCI Thesaurus)
This protein is comprised of most of the core-binding factor subunit beta fused to the C-terminal dimerization domain of myosin-11.
(CBFB/MYH11 Fusion Protein, NCI Thesaurus)
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