| / English Dictionary |
OSTEOCLAST
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Cell that functions in the breakdown and resorption of bone tissue
Classified under:
Hypernyms ("osteoclast" is a kind of...):
bone cell (a cell that is part of a bone)
Context examples:
Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.
(Odanacatib, NCI Thesaurus)
Osteoblasts synthesize bone matrix and form new bone while osteoclasts digest mineral matrix and old bone.
(Bone Remodeling, NCI Thesaurus)
A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.
(Bone Paget Disease, NCI Thesaurus)
A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels.
(Cinacalcet Hydrochloride, NCI Thesaurus)
Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover.
(Alendronic Acid, NCI Thesaurus)
Denosumab specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density.
(Denosumab, NCI Thesaurus)
Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease.
(Multitargeted Tyrosine Kinase Inhibitor PLX3397, NCI Thesaurus)
Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p.
(Clodronic Acid, NCI Thesaurus)
Bone Resorption Stimulation involves initiation of absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate and release of bone salts (phosphorus and, especially, calcium) into the extracellular fluid by osteoclasts, activated by parathyroid hormone.
(Bone Resorption Stimulation, NCI Thesaurus)
Bone Resorption Inhibition involves interference with, or restraint of, absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate and release of bone salts (phosphorus and, especially, calcium) into the extracellular fluid by osteoclasts, activated by parathyroid hormone.
(Bone Resorption Inhibition, NCI Thesaurus)
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