| / English Dictionary |
OXYGENASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An oxidoreductase that catalyzes the incorporation of molecular oxygen
Classified under:
Hypernyms ("oxygenase" is a kind of...):
oxidoreductase (an enzyme that catalyzes oxidation-reduction)
Context examples:
Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes.
(Ibuprofen, NCI Thesaurus)
Enzymes involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygenase, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase.
(Oxidative Stress Pathway, NCI Thesaurus/BIOCARTA)
Mefenamic acid inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes.
(Mefenamic Acid, NCI Thesaurus)
This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH).
(Nrf2 Activator RTA 408, NCI Thesaurus)
Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes.
(Nabumetone, NCI Thesaurus)
This allele, which encodes heme oxygenase 1 protein, plays a role in the conversion of heme to bilirubin and carbon monoxide.
(HMOX1 wt Allele, NCI Thesaurus)
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