| / English Dictionary |
PEPTIDASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
Synonyms:
peptidase; protease; proteinase; proteolytic enzyme
Classified under:
Hypernyms ("peptidase" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Hyponyms (each of the following is a kind of "peptidase"):
caspase (any of a group of proteases that mediate apoptosis)
ACE; angiotensin-converting enzyme; angiotensin converting enzyme (proteolytic enzyme that converts angiotensin I into angiotensin II)
plasminogen activator; urokinase (protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis)
renin (a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure)
Context examples:
This allele encodes putative macrophage-stimulating protein MSTP9, a non-functional member of the peptidase S1 family.
(MST1L wt Allele, NCI Thesaurus)
ACE is a di-peptidase, cleaving off 2 peptides from the c-terminal end of angiotensin.
(Angiotensin-converting Enzyme 2 Pathway, NCI Thesaurus/BIOCARTA)
A potent, long-acting, selective, orally bioavailable, pyrrolidinone-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
(Carmegliptin, NCI Thesaurus)
A potent, selective, orally bioavailable, fluoropyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
(Denagliptin, NCI Thesaurus)
This gene encodes a non-functional member of the peptidase S1 family.
(MST1L Gene, NCI Thesaurus)
Upon administration, the dipeptide bond in the melphalan-flufenamide compound is hydrolyzed by peptidases, which are overexpressed by certain cancer cells.
(Melphalan-Flufenamide Prodrug, NCI Thesaurus)
A potent, selective and orally bioavailable, cyanopyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
(Melogliptin, NCI Thesaurus)
LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes.
(L-Leucyl-L-Leucine Methyl Ester, NCI Thesaurus)
A potent, water soluble, selective and orally bioavailable, boronic acid-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
(Dutogliptin, NCI Thesaurus)
The benzoate salt form of alogliptin, a selective, orally bioavailable, pyrimidinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
(Alogliptin Benzoate, NCI Thesaurus)
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