| / English Dictionary |
PHILADELPHIA
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The largest city in Pennsylvania; located in the southeastern part of the state on the Delaware river; site of Independence Hall where the Declaration of Independence and the Constitution were signed; site of the University of Pennsylvania
Synonyms:
City of Brotherly Love; Philadelphia
Classified under:
Nouns denoting spatial position
Instance hypernyms:
city; metropolis; urban center (a large and densely populated urban area; may include several independent administrative districts)
Meronyms (parts of "Philadelphia"):
Benjamin Franklin Bridge (a suspension bridge across the Delaware River)
Independence Hall (the building in Philadelphia where the Declaration of Independence was signed)
Walt Whitman Bridge (a suspension bridge across the Delaware River)
Holonyms ("Philadelphia" is a part of...):
Keystone State; PA; Pa.; Pennsylvania (a Mid-Atlantic state; one of the original 13 colonies)
Context examples:
Philadelphia chromosome abnormality; t(9;22)(q34;q11) was found; bcr/abl gene rearrangement was not tested; therefore it is not known if present or not.
(Ph+/BCR Unknown, NCI Thesaurus)
An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that contain the Philadelphia chromosome.
(Imatinib, NCI Thesaurus)
CML is associated in most cases with a specific chromosomal defect, a translocation between chromosomes 9 and 22 that creates the Philadelphia chromosome.
(Inhibition of Cellular Proliferation by Gleevec Pathway, NCI Thesaurus/BIOCARTA)
INNO-406 specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML).
(Bafetinib, NCI Thesaurus)
The changed chromosome 22 with the fusion gene on it is called the Philadelphia chromosome.
(BCR-ABL fusion gene, NCI Dictionary)
Researchers from Children's Hospital of Philadelphia (CHOP) who conducted the study recommend follow-up investigations to further evaluate the device.
(Better IV Insertion Device, The Titi Tudorancea Bulletin)
A drug used to treat chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia.
(Iclusig, NCI Dictionary)
The Philadelphia translocation produces a BCR-ABL1 chimeric product required for induction and maintenance of leukemia.
(BCR Protein, NCI Thesaurus)
The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene.
(Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, NCI Thesaurus/WHO)
Derived from Rockefeller Swiss mice that were disseminated to the Institute of Cancer Research in Philadelphia (1948).
(ICR BR Mouse, NCI Thesaurus)
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