| / English Dictionary |
PIVOTAL
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Being of crucial importance
Example:
a polar principal
Synonyms:
pivotal; polar
Classified under:
Similar:
crucial; important (of extreme importance; vital to the resolution of a crisis)
Derivation:
pivot (the person in a rank around whom the others wheel and maneuver)
Context examples:
AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed in many tumors.
(AEG35156, NCI Thesaurus)
A class of organic compounds that contain nitrogen as the pivotal atom for functional groups.
(Amine, NCI Thesaurus)
ASK plays a pivotal role in the G1/S transition in mammalian cells and its function is essential for entry into S phase.
(CDC7L1 Kinase Complex, NCI Thesaurus)
A pivotal study will generally be well-controlled, randomized, of adequate size, and whenever possible, double-blind.
(Phase IIb Trial, NCI Thesaurus)
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