| / English Dictionary |
PLASMIN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An enzyme that dissolves the fibrin of blood clots
Synonyms:
fibrinolysin; plasmin
Classified under:
Hypernyms ("plasmin" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Hyponyms (each of the following is a kind of "plasmin"):
plasminogen (an inactive form of plasmin that occurs in plasma and is converted to plasmin by organic solvents)
Context examples:
Aminocaproic acid competitively reduces the conversion of plasminogen to plasmin by plasminogen activators.
(Aminocaproic Acid, NCI Thesaurus)
Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.
(Alteplase, NCI Thesaurus)
Inhibited by PAI-1, encoded by the PLAT Gene (Peptidase S1 Family), and cleaved by plasmin, tissue kallikrein, or factor XA to disulfide-linked A/B chains, tissue-type plasminogen activator plays a role in cell migration and tissue remodeling.
(Plasminogen Activator Interaction, NCI Thesaurus)
Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer formation and degradation.
(Fibrinolysis Pathway, NCI Thesaurus/BIOCARTA)
Aminocaproic acid competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots as well as fibrinogen and other plasma proteins including the procoagulant factors V and VIII.
(Aminocaproic Acid, NCI Thesaurus)
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