POTENTIATE

Pronunciation (US): (GB):

I. (verb)

Verb forms

Present simple: I / you / we / they potentiate ... he / she / it potentiates

Past simple: potentiated

Past participle: potentiated

-ing form: potentiating

Sense 1

Meaning:

Increase the effect of or act synergistically with (a drug or a physiological or biochemical phenomenon)

Example:

potentiate the drug

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "potentiate" is one way to...):

enhance; heighten; raise (increase)

Domain category:

drug (a substance that is used as a medicine or narcotic)

Sentence frame:

Something ----s something

Derivation:

potentiation ((medicine) the synergistic effect of two drugs given simultaneously)

Credits

Context examples:

In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.

(Androstane Steroid HE3235, NCI Thesaurus)

In addition, ALVAC(2) encodes the vaccinia virus (vv) E3L ad K3L genes, which may potentiate the translation of the NY-ESO and TRICOM genes.

(ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine, NCI Thesaurus)

Upon vaccination, the genetically modified cells secrete GM-CSF, thereby potentiating a tumor-specific T cell response against breast cancer cell-asociated antigens.

(Allogeneic GM-CSF-Secreting Breast Cancer Vaccine, NCI Thesaurus)

This agent may potentiate the anti-tumor activity of alkylating agents.

(Methoxyamine, NCI Thesaurus)

As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling.

(Duloxetine hydrochloride, NCI Thesaurus)

A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration.

(Ditiocarb, NCI Thesaurus)

In addition, this agent is capable of inhibiting rapid desensitization of the ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors, thereby potentiating glutamate responses which may induce seizures activity.

(Cyclothiazide, NCI Thesaurus)

Unlike doxorubicin, this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand cross-links, thereby potentiating its doxorubicin-like cytotoxicity.

(Morpholinodoxorubicin, NCI Thesaurus)

In addition, nebivolol potentiates nitric oxide (NO), thereby relaxing vascular smooth muscle and exerting a vasodilatory effect.

(Nebivolol, NCI Thesaurus)

L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency.