| / English Dictionary |
PROGRAMMED CELL DEATH
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival
Synonyms:
apoptosis; caspase-mediated cell death; programmed cell death
Classified under:
Nouns denoting natural phenomena
Hypernyms ("programmed cell death" is a kind of...):
cell death; necrobiosis ((physiology) the normal degeneration and death of living cells (as in various epithelial cells))
Context examples:
The RIPK1 gene encodes for the RIPK1 protein, which is involved in the body’s response to inflammation and programmed cell death.
(Researchers discover new autoinflammatory disease and uncover its biological cause, National Institutes of Health)
Oxidative stress is one factor that can trigger programmed cell death.
(Free Radical Induced Apoptosis Pathway, NCI Thesaurus/BIOCARTA)
This allele, which encodes programmed cell death 1 ligand 1 protein, plays a role in the regulation of T cell stimulation and proliferation.
(CD274 wt Allele, NCI Thesaurus)
Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, and cytotoxic T cells.
(Caspase Cascade Pathway, NCI Thesaurus/BIOCARTA)
A human, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1) with potential immunomodulating and antineoplastic activities.
(Anti-PD-L1 Monoclonal Antibody MPDL3280A, NCI Thesaurus)
A monoclonal antibody directed against B7H1 (B7 homolog 1; programmed cell death ligand 1) with potential immunostimulating activity.
(Anti-B7H1 Monoclonal Antibody MEDI4736, NCI Thesaurus)
A monoclonal antibody directed against the human programmed cell death 1 (PD-1) protein, with potential immunomodulating and antineoplastic activity.
(Anti-PD-1 Monoclonal Antibody AMP-514, NCI Thesaurus)
This ultimately induces programmed cell death.
(Amsacrine Lactate, NCI Thesaurus)
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others that are caspase independent.
(AIF Pathway, NCI Thesaurus/BIOCARTA)
Overexpression of the CASP7 gene promotes programmed cell death.
(CASP7 wt Allele, NCI Thesaurus)
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