PROLIFERATION

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

Growth by the rapid multiplication of parts

Classified under:

Hypernyms ("proliferation" is a kind of...):

development; growing; growth; maturation; ontogenesis; ontogeny ((biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level)

Derivation:

proliferate (cause to grow or increase rapidly)

proliferate (grow rapidly)

Sense 2

Meaning:

A rapid increase in number (especially a rapid increase in the number of deadly weapons)

Example:

the proliferation of nuclear weapons

Classified under:

Nouns denoting natural processes

Hypernyms ("proliferation" is a kind of...):

growth; increase; increment (a process of becoming larger or longer or more numerous or more important)

Antonym:

non-proliferation; nonproliferation (the prevention of something increasing or spreading (especially the prevention of an increase in the number of countries possessing nuclear weapons))

Derivation:

proliferate (cause to grow or increase rapidly)

proliferate (grow rapidly)

Credits

Context examples:

They are easily targeted with a mitochondrial inhibitor or a cell cycle inhibitor, which would prevent their proliferation.

(‘Energetic Cancer Cells’ May Be Origin of Cancer Spread, The Titi Tudorancea Bulletin)

They also performed further assays to test the ability of these 10 polymers to support chondrocyte proliferation to produce cartilage matrix in long-term cultures.

(Scientists design a new hydrogel that helps regenerate cartilage, University of Granada)

We knew it could play an important role in cell regulation — for example, in proliferation or development.

(Researchers Zero-In on Cholesterol's Role in Cells, The Titi Tudorancea Bulletin)

MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK-dependent cell signaling and the inhibition of tumor cell proliferation.

(MEK Inhibitor RO4987655, NCI Thesaurus)

MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation.

(MEK-1/MEKK-1 Inhibitor E6201, NCI Thesaurus)

This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor.

(MEK Inhibitor MEK162, NCI Thesaurus)

MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor GDC-0623, NCI Thesaurus)

Altogether, these IFN-g-mediated effects may result in an inhibition of tumor cell proliferation and tumor cell death.

(Adenovirus-Interferon-Gamma TG1042, NCI Thesaurus)

The intestinal epithelial cells of mice fed the emulsifiers also had higher levels of both cell death and proliferation.

(Food additives promote inflammation, colon cancer in mice, National Institutes of Health)

MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.