/ English Dictionary

PROTEOLYSIS

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

The hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds

Classified under:

Nouns denoting natural processes

Hypernyms ("proteolysis" is a kind of...):

chemical action; chemical change; chemical process ((chemistry) any process determined by the atomic and molecular composition and structure of the substances involved)

Derivation:

proteolytic (of or relating to proteolysis)

Credits

 Context examples: 

This protein is involved in the modulation of proteolysis.

(Pappalysin-1, NCI Thesaurus)

This allele, which encodes elafin protein, is involved in the regulation of connective tissue proteolysis.

(PI3 wt Allele, NCI Thesaurus)

This protein plays a role in the mediation of proteolysis.

(Plasma Kallikrein, NCI Thesaurus)

This allele, which encodes pappalysin-1 protein, plays a role in both pregnancy and the mediation of proteolysis.

(PAPPA wt Allele, NCI Thesaurus)

Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract.

(Pancreatic Proteolytic Enzymes, NCI Thesaurus)

This protein is involved in the proteolysis of extracellular matrix proteins.

(Myeloblastin, NCI Thesaurus)

Active gamma secretase requires PS-1 N-terminal fragment and a C-terminal fragment and is unique in catalyzing proteolysis within the transmembrane region of proteins.

(Notch and Wnt Signaling Pathway, NCI Thesaurus/BIOCARTA)

Proteasome inhibitor ONX 0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome; this may result in an accumulation of unwanted or misfolded proteins.

(Oprozomib, NCI Thesaurus)

Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

(Carfilzomib, NCI Thesaurus)

This protein plays a role in both proteolysis and apoptosis.

(Caspase-4, NCI Thesaurus)

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