PYRIMIDINE

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

A heterocyclic organic compound with a penetrating odor

Classified under:

Nouns denoting substances

Hypernyms ("pyrimidine" is a kind of...):

organic compound (any compound of carbon and another element or a radical)

Sense 2

Meaning:

Any of several basic compounds derived from pyrimidine

Classified under:

Nouns denoting substances

Hypernyms ("pyrimidine" is a kind of...):

alkali; base (any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water)

Hyponyms (each of the following is a kind of "pyrimidine"):

C; cytosine (a base found in DNA and RNA and derived from pyrimidine; pairs with guanine)

T; thymine (a base found in DNA (but not in RNA) and derived from pyrimidine; pairs with adenine)

Credits

Context examples:

An antimetabolite (pyrimidine analogue) antineoplastic derivative of 5-fluorouracil.

(Carmofur, NCI Thesaurus)

A pyrimidine nucleoside analogue of cytidine with antineoplastic activity.

(Azacitidine, NCI Thesaurus)

A synthetic derivative of pyrimidine with antineoplastic activity.

(Penclomedine, NCI Thesaurus)

Azotomycin inhibits glutamine-dependent enzymes involved in purine and pyrimidine biosynthesis, resulting in inhibition of DNA synthesis.

(Azotomycin, NCI Thesaurus)

The orally bioavailable bismesylate salt of a potent small-molecule thieno[3,2-d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) isoforms p100alpha and p100delta with potential antineoplastic activity.

(PI3K Inhibitor GDC-0941 Bismesylate, NCI Thesaurus)

Nucleotide transversions change the purine-pyrimidine orientation of a DNA sequence.

(Nucleotide Transversion Abnormality, NCI Thesaurus)

Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis.

(Brequinar, NCI Thesaurus)

The monomer structure (nucleoside) contains either a purine or pyrimidine base linked to a deoxyribose or ribose carbohydrate group.

(Nucleic Acids, Nucleosides, and Nucleotides, NCI Thesaurus)

The process of determining the sequence of purines and pyrimidines in nucleic acids and polynucleotides.

(Nucleic Acid Sequencing, NCI Thesaurus)

Multiple point mutations in a DNA sequence from eukaryotic or prokaryotic organisms in which each mutation occurs by substitution of a purine base for a pyrimidine base or vice versa.