| / English Dictionary |
RAS
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The network in the reticular formation that serves an alerting or arousal function
Synonyms:
RAS; reticular activating system
Classified under:
Hypernyms ("RAS" is a kind of...):
neural net; neural network (any network of neurons or nuclei that function together to perform some function in the body)
Holonyms ("RAS" is a part of...):
reticular formation; RF (a complex neural network in the central core of the brainstem; monitors the state of the body and functions in such processes as arousal and sleep and attention and muscle tone)
Context examples:
NF1 contains a GAP-related domain that down regulates p21(RAS) by stimulating its GTPase activity.
(Neurofibromin, NCI Thesaurus)
This pathway is initiated through recruitment and activation of Shc, which leads to ras activation through Grb-2 and Sos-1.
(Nerve Growth Factor Pathway, NCI Thesaurus/BIOCARTA)
Activation of KSR leads to further mitochondrial stimulation or association with RAS and activation of the Raf1 cascade leading to proliferation or differentiation.
(Ceramide Signaling Pathway BioCarta, NCI Thesaurus/BIOCARTA)
In mammalian cells, GPS2 has been shown to suppress RAS- and mitogen-activated protein kinase-mediated signaling and interfere c-Jun N-terminal Kinase activation.
(G Protein Pathway Suppressor 2 Protein, NCI Thesaurus/LocusLink)
In addition, antineoplastons may inhibit RAS oncogene expression and activate the tumor suppressor gene p53, resulting in cell differentiation and apoptosis.
(Antineoplaston Agent, NCI Thesaurus)
Ras/Map kinase activation by the PAR receptors also activates phospholipase A2.
(Aspirin Inhibition of Platelet Activation Pathway, NCI Thesaurus/BIOCARTA)
In addition, this agent may exhibit antihypertensive activity through the inhibition of renin secretion by juxtaglomerular epithelioid (JGE) cells in the kidney, thus inhibiting activation of the renin-angiotensin system (RAS).
(Bisoprolol Fumarate, NCI Thesaurus)
This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis.
(Antineoplaston AS2-1, NCI Thesaurus)
A synthetic antibody targeted against a cell surface glycoprotein (gp74) on a human c-Ha-ras oncogene transformed cell line.
(Monoclonal Antibody 45-2D9, NCI Thesaurus)
AKAP13 stimulates RHO/RAC, but not CDC42 or RAS.
(A Kinase Anchor Protein 13, NCI Thesaurus)
YOU MAY ALSO LIKE
