| / English Dictionary |
REPRESSOR
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An agent that represses
Synonyms:
represser; repressor
Classified under:
Nouns denoting natural objects (not man-made)
Hypernyms ("repressor" is a kind of...):
agent (an active and efficient cause; capable of producing a certain effect)
Context examples:
This allele, which encodes transcriptional repressor CTCF protein, may play a role in transcriptional repression and establishment of heterochromatin boundaries.
(CTCF wt Allele, NCI Thesaurus)
The homeo domain is structurally similar to the helix-turn-helix DNA-binding domain of CRO and Lambda repressor.
(Homeo Domain, NCI Thesaurus)
The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptional repressor Snail, a master regulator of epithelial to mesenchymal transitions.
(MTA3 Pathway, NCI Thesaurus/BIOCARTA)
During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21.
(Negative Regulation of G1 Phase, NCI Thesaurus)
This allele, which encodes histone deacetylase 2 protein, is involved in both the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4) and the formation of transcriptional repressor complexes.
(HDAC2 wt Allele, NCI Thesaurus)
The SIN3 co-repressor specifically associates with some transcriptional repressors, including members of the MAD family important in development.
(mSin3, NCI Thesaurus)
This suggests that other co-activators might also have specific repressors, adding another layer of combinatorial complexity in transcriptional regulation.
(PGC1a Regulation Pathway, NCI Thesaurus/BIOCARTA)
Phosphorylation of Rb by CDK4/6 and CDK2 dissociates the Rb-repressor complex, permitting transcription of S-phase genes encoding for proteins that amplify the G1 to S phase switch and that are required for DNA replication.
(G1/S Checkpoint Pathway, NCI Thesaurus/BIOCARTA)
They compete with MYC for the protein MAX and for consensus DNA binding sites and to recruit SIN3 proteins and their associated co-repressors.
(mSin3, NCI Thesaurus)
Gene-specific targeting of the SIN3 co-repressor complex by DNA-bound repressors is important in eukaryotic gene silencing.
(mSin3, NCI Thesaurus)
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