| / English Dictionary |
RHABDOMYOSARCOMA
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A highly malignant neoplasm derived from striated muscle
Synonyms:
rhabdomyosarcoma; rhabdosarcoma
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("rhabdomyosarcoma" is a kind of...):
sarcoma (a usually malignant tumor arising from connective tissue (bone or muscle etc.); one of the four major types of cancer)
Hyponyms (each of the following is a kind of "rhabdomyosarcoma"):
embryonal rhabdomyosarcoma; embryonal rhabdosarcoma (form of rhabdomyosarcoma occurring mainly in infants and children)
alveolar rhabdomyosarcoma; alveolar rhabdosarcoma (form of rhabdomyosarcoma occurring mainly in adolescents and young adults)
pleomorphic rhabdomyosarcoma; pleomorphic rhabdosarcoma (form of rhabdomyosarcoma that affects limb muscles of older adults)
Context examples:
People with Costello syndrome have an increased risk of certain types of cancer, such as rhabdomyosarcoma (a soft tissue tumor) and neuroblastoma (cancer of immature nerve cells).
(Costello syndrome, NCI Dictionary)
PAX3/FKHR fusion proteins are frequently found in patients with rhabdomyosarcomas.
(PAX3/FKHR Peptide Vaccine, NCI Thesaurus)
Representative examples include angiosarcoma, liposarcoma, leiomyosarcoma, rhabdomyosarcoma, and extraskeletal osteosarcoma.
(Breast Sarcoma, NCI Thesaurus)
The malignant component most often is sarcomatous (rhabdomyosarcoma or undifferentiated sarcoma) or carcinomatous (squamous cell carcinoma or adenocarcinoma).
(Central Nervous System Teratoma with Malignant Transformation, NCI Thesaurus)
The majority of the cases are rhabdomyosarcomas.
(Orbit Sarcoma, NCI Thesaurus)
In alveolar rhabdomyosarcoma, the wild-type allele is involved in a translocation t(1;13)(p36;q14) with the FOXO1 wild-type allele.
(PAX7 wt Allele, NCI Thesaurus)
This allele, which encodes MIR29B2 RNA, plays a role in lung cancer, cholangiocarcinoma, rhabdomyosarcoma, chronic lymphocytic leukemia, acute myeloid leukemia, Alzheimer's disease and type 2 diabetes.
(MIR29B2 wt Allele, NCI Thesaurus)
Aberrant alterations in this region generate variant alleles that are associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.
(PHLDA2 wt Allele, NCI Thesaurus)
Representative examples include angiosarcoma, undifferentiated (embryonal) sarcoma, rhabdomyosarcoma, and leiomyosarcoma.
(Liver Sarcoma, NCI Thesaurus)
This rearrangement is associated with rare variants of alveolar rhabdomyosarcoma.
(PAX3/FOXO4 Fusion Gene, NCI Thesaurus)
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