| / English Dictionary |
SECRETASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)
Classified under:
Hypernyms ("secretase" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Context examples:
Activated Notch cleavage by TACE and presenilin dependent gamma-secretase releases the intracellular domain to form a transcription complex with RBP-J kappa to activate enhancer of split genes.
(Notch Homolog 1, NCI Thesaurus)
This allele, which encodes beta-secretase 1 protein, is involved in proteolytic processing.
(BACE1 wt Allele, NCI Thesaurus)
Widely expressed APP is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, and cytotoxic fragments.
(Amyloid Beta A4 Protein Precursor, NCI Thesaurus)
Gamma-secretase subunit PEN-2 (101 aa, ~12 kDa) is encoded by the human PSENEN gene.
(Gamma-Secretase Subunit PEN-2, NCI Thesaurus)
Other proteins such as nicastrin may also be components of the gamma-secretase.
(Notch and Wnt Signaling Pathway, NCI Thesaurus/BIOCARTA)
Labeling of presenilin with irreversible gamma-secretase transition state inhibitors indicates that is itself in fact the site of protease activity.
(Notch Proteolysis and Signaling Pathway, NCI Thesaurus/BIOCARTA)
A selective gamma secretase (GS) inhibitor with potential antitumor activity.
(Gamma Secretase Inhibitor PF-03084014, NCI Thesaurus)
Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation.
(Gamma-Secretase Inhibitor RO4929097, NCI Thesaurus)
Gamma-secretase cuts APP within the transmembrane domain at amino acids 40 and 42, releasing the beta-amyloid fragment containing residues 1-40/42 as well as shorter products such as p3 (residues 17-40/42) that requires alpha-secretase cleavage.
(Amyloid Beta-Peptide Pathway, NCI Thesaurus/BIOCARTA)
Active gamma secretase requires PS-1 N-terminal fragment and a C-terminal fragment and is unique in catalyzing proteolysis within the transmembrane region of proteins.
(Notch and Wnt Signaling Pathway, NCI Thesaurus/BIOCARTA)
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