| / English Dictionary |
SUBSTANTIA NIGRA
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease
Synonyms:
locus niger; nucleus niger; substantia nigra
Classified under:
Hypernyms ("substantia nigra" is a kind of...):
neural structure (a structure that is part of the nervous system)
Holonyms ("substantia nigra" is a part of...):
mesencephalon; midbrain (the middle portion of the brain)
Context examples:
This study showed that a greater free water increase in the substantia nigra was associated with a decrease in dopamine neuron activity in one of these nearby regions, supporting the idea that free water changes are related to progression of the disease.
(Waterlogged brain region helps scientists gauge damage caused by Parkinson’s disease, National Institutes of Health)
Researchers have found that NM-MRI signal is lower in the substantia nigra of people with Parkinson’s disease, reflecting the cell death that occurs in these patients.
(Neuromelanin-sensitive MRI identified as a potential biomarker for psychosis, National Institutes of Health)
The researchers found decreases in NM-MRI signal in those with Parkinson’s disease in the lateral, posterior, and ventral areas of the substantia nigra — findings that correspond to the known anatomical distribution of cell loss in this brain area in Parkinson’s disease.
(Neuromelanin-sensitive MRI identified as a potential biomarker for psychosis, National Institutes of Health)
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