SUBSTITUTION

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

The act of putting one thing or person in the place of another:

Example:

he sent Smith in for Jones but the substitution came too late to help

Synonyms:

commutation; exchange; substitution

Classified under:

Nouns denoting acts or actions

Hypernyms ("substitution" is a kind of...):

change (the action of changing something)

Hyponyms (each of the following is a kind of "substitution"):

replacement; replacing (the act of furnishing an equivalent person or thing in the place of another)

subrogation ((law) the act of substituting of one creditor for another)

ablactation; weaning (the act of substituting other food for the mother's milk in the diet of a child or young mammal)

Derivation:

substitute (put in the place of another; switch seemingly equivalent items)

Sense 2

Meaning:

An event in which one thing is substituted for another

Example:

the replacement of lost blood by a transfusion of donor blood

Synonyms:

permutation; replacement; substitution; switch; transposition

Classified under:

Nouns denoting natural events

Hypernyms ("substitution" is a kind of...):

fluctuation; variation (an instance of change; the rate or magnitude of change)

Derivation:

substitute (put in the place of another; switch seemingly equivalent items)

substitute (be a substitute)

Credits

Context examples:

This agent has a high barrier to resistance, however, a substitution mutation (S282T) on HCV NS5B impairs mericitabine's activity significantly.

(Mericitabine, NCI Thesaurus)

A point mutation involving the substitution of Cytosine (a pyrimidine base) for Guanosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms.

(Guanosine to Cytosine Transversion Abnormality, NCI Thesaurus)

This includes arenes and their substitution products (e.g., benzene, naphthalene, toluene).

(Aromatic Compounds, NCI Thesaurus)

A point mutation involving the substitution of Adenosine (a purine base) for Guanosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms.

(Guanosine to Adenosine Transition Abnormality, NCI Thesaurus)

Point mutations at various locations in a DNA sequence from eukaryotic or prokaryotic organisms in which a nucleotide substitution, deletion or insertion has occurred at each affected site.

(Mixed Nucleotide Abnormalities, NCI Thesaurus)

Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS.

(Moxalactam, NLM, Medical Subject Headings)

A point mutation that involves the substitution of a pyrimidine base for a different pyrimidine base or substitution of a purine base for a different purine base.

(Nucleotide Transition Abnormality, NCI Thesaurus)

A point mutation that involves the substitution of a pyrimidine base for a purine base or substitution of a purine base for a pyrimidine base.

(Nucleotide Transversion Abnormality, NCI Thesaurus)

As a GH analog, the structure of pegvisomant is similar to that of native GH with the exception of 9 amino acid substitutions.

(Pegvisomant, NCI Thesaurus)

Multiple point mutations in a DNA sequence from eukaryotic or prokaryotic organisms in which each mutation occurs by substitution of a purine base for a pyrimidine base or vice versa.