| / English Dictionary |
SUPERFAMILY
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
(biology) a taxonomic group ranking below an order but above a family
Classified under:
Nouns denoting groupings of people or objects
Hypernyms ("superfamily" is a kind of...):
taxon; taxonomic category; taxonomic group (animal or plant group having natural relations)
Domain category:
biological science; biology (the science that studies living organisms)
Context examples:
A taxonomic category above superfamily and below infraorder.
(Parvorder, NCI Thesaurus)
VEGFR2, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the VEGFR superfamily and plays key roles in tumor cell proliferation, survival, invasion and tumor angiogenesis.
(Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes, NCI Thesaurus)
PD-1, a transmembrane protein in the Ig superfamily, negatively regulates T-cell activation and effector function when activated by its ligands, and plays an important role in tumor evasion from host immunity.
(Anti-PD-1 Monoclonal Antibody AMP-514, NCI Thesaurus)
Unlike most TGFB superfamily members, in which the amino acid sequence is completely conserved, PLAB shares only 70% amino acid identity with its rodent counterparts.
(Placental TGF-Beta, NCI Thesaurus)
Based upon sequence analysis the AIM1 protein appears to be a member of the beta-gamma crystallin superfamily.
(Absent in Melanoma 1, NCI Thesaurus/from OMIM)
The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm.
(Apoptosis Pathway, NCI Thesaurus/KEGG)
This allele, which encodes tumor necrosis factor receptor superfamily member 16 protein, plays a role in several biological process through signal transduction.
(NGFR wt Allele, NCI Thesaurus)
ATP-Binding Cassette, Sub-Family B, Member 6, encoded by the ABCB6 gene, is a membrane-associated protein of the superfamily of ATP-binding cassette (ABC) transporters.
(ATP-Binding Cassette, Sub-Family B, Member 6, NCI Thesaurus)
The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families.
(Microtubule, NCI Thesaurus/LocusLink)
P-gp, encoded by the MDR-1 gene, is a member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters; it prevents the intestinal uptake and intracellular accumulation of various cytotoxic agents.
(Oraxol, NCI Thesaurus)
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