SUPEROXIDE

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

The univalent anion O2-

Example:

much of the O2 supporting cellular respiration is reduced to the superoxide anion O2-

Synonyms:

superoxide; superoxide anion

Classified under:

Nouns denoting substances

Hypernyms ("superoxide" is a kind of...):

anion (a negatively charged ion)

Sense 2

Meaning:

A metallic oxide containing the univalent anion O2-

Classified under:

Nouns denoting substances

Hypernyms ("superoxide" is a kind of...):

oxide (any compound of oxygen with another element or a radical)

Credits

Context examples:

A manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and chemo/radioprotective activities.

(Imisopasem Manganese, NCI Thesaurus)

Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-).

(Nifurtimox, NCI Thesaurus)

The components in Antrodia cinnamomea supplement are rather complex, however, rich in triterpenoids, polysaccharides, nucleosides (adenosine) nucleic acids, superoxide dismutase, other small molecular weight proteins and steroid like compounds.

(Antrodia cinnamomea Supplement, NCI Thesaurus)

Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS) via aberrant superoxide chemistry.

(Amyotrophic Lateral Sclerosis Pathway, NCI Thesaurus/KEGG)

ATN-224 selectively chelates the copper ion in superoxide dismutase 1 (SOD1) in endothelial cells, thereby depleting SOD1 of copper and inhibiting its activity.

(Bis(choline)tetrathiomolybdate, NCI Thesaurus)

This species is motile, spore forming, catalase and superoxide dismutase positive, indole negative, and reduces nitrate, hydrolyzes starch, and does not ferment glucose or lactose.

(Bacillus subtilis, NCI Thesaurus)

Bleomycin antibiotics form complexes with iron that react with molecular oxygen to produce superoxide and hydroxyl free radicals, causing single- and double-stranded breaks in DNA.

(Bleomycin Antibiotic, NCI Thesaurus)

Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA.

(Peplomycin, NCI Thesaurus)

A derivative of pyridoxyl ethyldiamine (PLED) and mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with antioxidant, metal chelating and potential chemoprotective activities.

(PLED-based MnSOD Mimetic, NCI Thesaurus)

Beta-lapachone (b-lap) is bioactivated by NAD(P)H:quinone oxidoreductase-1 (NQO1), creating a futile oxidoreduction that generates high levels of superoxide.