| / English Dictionary |
THROMBIN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An enzyme that acts on fibrinogen in blood causing it to clot
Classified under:
Hypernyms ("thrombin" is a kind of...):
coagulase (an enzyme that induces coagulation)
Context examples:
Orthologous to human thrombin, batroxobin activates soluble fibrinogen into fibrin and facilitates blood coagulation, thereby can be used in substitution of thrombin in quantitative thrombin time test.
(Batroxobin, NCI Thesaurus)
Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors.
(Bivalirudin, NCI Thesaurus)
A unit of anti-coagulation potency of antithrombin determined as the amount of antithrombin that neutralizes one unit of World Health Organization preparation 89/588 of thrombin.
(Anti-Thrombin Unit, NCI Thesaurus)
Platelets from mice lacking the PAR4 gene are not activated by thrombin and are impaired in clotting, supporting the importance of thrombin signaling through PAR4 in clotting.
(Aspirin Inhibition of Platelet Activation Pathway, NCI Thesaurus/BIOCARTA)
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pressure regulating peptide angiotensin.
(Bioactive Peptide Signaling Pathway, NCI Thesaurus/BIOCARTA)
Binding of thrombin further activates the platelets.
(Acute Myocardial Infarction Pathway, NCI Thesaurus/BIOCARTA)
Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and preventing formation of cross-linked fibrin clots.
(Apixaban, NCI Thesaurus)
This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation.
(Acenocoumarol, NCI Thesaurus)
As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation.
(Aprotinin, NCI Thesaurus)
This activation occurs at the transcriptional level and a thrombin response element was identified in the promoter of the PDGF B-chain gene.
(DBPB Transcriptional Activation Pathway, NCI Thesaurus/BIOCARTA)
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