TRANSLOCATION

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

(genetics) an exchange of chromosome parts

Example:

translocations can result in serious congenital disorders

Classified under:

Nouns denoting natural processes

Hypernyms ("translocation" is a kind of...):

biological process; organic process (a process occurring in living organisms)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

Derivation:

translocate (transfer (a chromosomal segment) to a new position)

Sense 2

Meaning:

The transport of dissolved material within a plant

Classified under:

Nouns denoting natural processes

Hypernyms ("translocation" is a kind of...):

biological process; organic process (a process occurring in living organisms)

Credits

Context examples:

A fusion gene that results from a chromosomal translocation t(11;17)(q23;q12-21) which fuses the 5' half of the MLL gene to the 3' half of the LASP1 gene.

(MLL/LASP1 Fusion Gene, NCI Thesaurus)

Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7.

(Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome, NCI Thesaurus)

A fusion gene that results from a chromosomal translocation t(10;11)(p12;q23) which fuses the 5' half of the MLL gene to the 3' half of the MLLT10 gene.

(MLL/MLLT10 Fusion Gene, NCI Thesaurus)

A fusion gene that results from a chromosomal translocation t(9;11)(p22;q23) which fuses the 5' half of the MLL gene to the 3' end of the MLLT3 gene.

(MLL/MLLT3 Fusion Gene, NCI Thesaurus)

A fusion gene that results from a chromosomal translocation t(6;11)(q27;q23) which fuses the 5' half of the MLL gene to most of the MLLT4 gene.

(MLL/MLLT4 Fusion Gene, NCI Thesaurus)

A term referring to acute myeloid leukemias with rearrangement of the MLL gene which results in translocations with various genes other than the MLLT3 (AF9) gene.

(Acute Myeloid Leukemia with Variant MLL Translocations, NCI Thesaurus)

A fusion gene that results from a chromosomal translocation t(11;19)(q23;p13.3) which fuses the 5' half of the MLL gene to most of the MLLT1 gene.

(MLL/MLLT1 Fusion Gene, NCI Thesaurus)

It is characterized by the t(15;17)(q22;q12) translocation.

(Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML-RARA, NCI Thesaurus/WHO)

A fusion gene that results from a chromosomal translocation t(11;12)(q23;q13) which fuses exon 9 of the MLL gene to most of the SARNP gene.

(MLL/SARNP Fusion Gene, NCI Thesaurus)

A fusion gene that results from a chromosomal translocation t(10;11)(p11.2;q23) which fuses either exon 6 or 7 of the MLL gene to nucleotide 433 of the ABI1 gene.