URACIL

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

A base containing nitrogen that is found in RNA (but not in DNA) and derived from pyrimidine; pairs with adenine

Synonyms:

U; uracil

Classified under:

Nouns denoting substances

Hypernyms ("uracil" is a kind of...):

base; nucleotide (a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA))

Holonyms ("uracil" is a substance of...):

ribonucleic acid; RNA ((biochemistry) a long linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell)

Credits

Context examples:

Following oral administration of ER 5-FC, the 5-FC is deaminated to its active metabolite 5-fluorouracil (5-FU). 5-FU replaces uracil during RNA synthesis, which consequently inhibits downstream protein synthesis.

(Extended Release Flucytosine, NCI Thesaurus)

First, a denatured DNA sample is treated with bisulfite which converts non-methylated cytosine to uracil.

(Bisulfite Sequencing, NCI Thesaurus)

A molecule consisting of a nitrogen-containing base (adenine, guanine, thymine, or cytosine in DNA; adenine, guanine, uracil, or cytosine in RNA), a phosphate group, and a sugar (deoxyribose in DNA; ribose in RNA).

(Nucleotide, NCI Dictionary)

This allele, which encodes dihydropyrimidine dehydrogenase [NADP+] protein, plays a role in the reduction of uracil, thymine and the drug 5-fluorouracil.

(DPYD wt Allele, NCI Thesaurus)

After intratumoral injection, fluorouracil is converted into the active metabolite 5-fluoroxyuridine monophosphate that competes with uracil during RNA synthesis while another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate, inhibits thymidylate synthase and, so, DNA synthesis.

(Fluorouracil-E Therapeutic Implant, NCI Thesaurus)

Upon implantation and subsequent release, fluorouracil is converted into the active metabolite 5-fluoroxyuridine monophosphate that competes with the pyrimidine uracil during RNA synthesis while another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate, inhibits thymidylate synthase and thus DNA synthesis.

(Fluorouracil Implant, NCI Thesaurus)

A subunit of DNA or RNA consisting of a nitrogenous base (adenine, guanine, thymine, or cytosine in DNA; adenine, guanine, uracil, or cytosine in RNA), a phosphate molecule, and a sugar molecule (deoxyribose in DNA and ribose in RNA).

(Nucleotide, NCI Thesaurus)

The uracil causes higher amounts of 5-FU to stay inside the cells and kill them.

(Ftorafur, NCI Dictionary)

Also called 1-(2’-deoxy-2’-fluoro-ß-D-arabinofuranosyl) uracil.

(FAU, NCI Dictionary)