VACCINIA

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

A viral disease of cattle causing a mild skin disease affecting the udder; formerly used to inoculate humans against smallpox

Synonyms:

cowpox; vaccinia

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("vaccinia" is a kind of...):

pox (a contagious disease characterized by purulent skin eruptions that may leave pock marks)

animal disease (a disease that typically does not affect human beings)

Sense 2

Meaning:

A local infection induced in humans by inoculation with the virus causing cowpox in order to confer resistance to smallpox; normally lasts three weeks and leaves a pitted scar

Synonyms:

vaccina; vaccinia; variola vaccina; variola vaccine; variola vaccinia

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("vaccinia" is a kind of...):

infection (the pathological state resulting from the invasion of the body by pathogenic microorganisms)

Hyponyms (each of the following is a kind of "vaccinia"):

progressive vaccinia; vaccinia gangrenosa (a severe or even fatal form of vaccinia that occurs mainly in persons with an immunological deficiency; characterized by progressive enlargement of the initial lesion)

Credits

Context examples:

A cancer vaccine consisting of a recombinant modified vaccinia Ankara (MVA) viral vector encoding genes for prostate specific antigen (PSA) and prostate acid phosphatase (PAP) with potential immunostimulatory and antineoplastic activities.

(MVA-PSA/PAP Prostate Cancer Vaccine, NCI Thesaurus)

CMV pp65 peptide antigen is used in recombinant vaccinia virus as an HLA-A-restricted epitope to produce vaccines and specific CD8+ and CD4+ cell responses against CMV infection, a serious complication of allogeneic bone marrow transplantation (BMT).

(CMV N495 Peptide, NCI Thesaurus)

A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3.

(Inalimarev, NCI Thesaurus)

A cancer vaccine consisting of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the gene for the CD4 epitope-rich C-terminal domain of the Epstein Barr Virus (EBV) antigen EBNA1 and fused to the full-length of the EBV-associated antigen latent membrane protein 2 (LMP2), with potential immunostimulatory and antineoplastic activities.

(MVA-EBNA1/LMP2 Vaccine, NCI Thesaurus)

The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attenuated, replication-defective vaccinia strain incapable of virion assembly.

(MVA-FCU1 TG4023, NCI Thesaurus)

An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential bioluminescent and antineoplastic activities.

(Light-Emitting Oncolytic Vaccinia Virus GL-ONC1, NCI Thesaurus)

Upon administration, modified vaccinia Ankara (Bavarian Nordic)-HER2 vaccine may stimulate the host immune system to mount humoral and cytotoxic T lymphocyte responses against HER2-expressing tumor cells, resulting in tumor cell lysis.

(Modified Vaccinia Ankara (Bavarian Nordic)-HER2 Vaccine, NCI Thesaurus)

In a cancer vaccine application, tumor cells taken from the host may be adsorbed with inactivated vaccinia virus and returned to the host, where the modified tumor cells may stimulate an anti-tumor immune response.

(Inactivated Vaccinia Virus, NCI Thesaurus)

While vaccinia displays a natural tumor cell tropism, deletion of the thymidine kinase gene increases the tumor selectivity of vaccinia by limiting viral replication to transformed cells. hGM-CSF expression by this agent may help recruit antigen processing cells (APCs), such as denritic cells and macrophages, to virally infected tumor cells, initiating a systemic antitumoral immune response.